Inflammation in Pancreatic Islets: Contribution of Islet Macrophages

Janice PangMy name is Janice Pang, and I’m currently in grade 9. In school, I actively take part in the grade 9 advisory council and is a member of the volleyball team. Outside of school, I enjoy going curling and competing in the Optimist Junior Curling League. Previously, I have participated in the 2012 Canada-Wide Science Fair. This year microbiology continues to be an interest of mine. To have the opportunity to continue conducting experiments in a research lab was amazing.

The passion I had for learning about the pathogenesis of type 2 diabetes had inspired me to do this project. In the future, I hope to continue researching about type 2 diabetes. As well, if students are thinking about doing a project, starting early will be the key to success.

Pancreatic islets were treated with IAPP to identify whether IAPP activates caspase-1 in pancreatic islets. The effects of islet macrophages on insulin secretion and production was also investigated. This study provides a better understanding of the pathogenesis of type 2 diabetes and suggest a therapeutic treatment in which the stimulus of inflammation can be targeted, to improve insulin secretion and beta cell function.

Winner of the Excellence Award - Gold Medal (Intermediate) at the Canada Wide Science Fair 2013

Canada Wide Science Fair

The Canada-Wide Science Fair (CWSF®) is a national event that brings together 500 top young scientists (in grades 7-12/Cégep) from across the country to compete for highly prized cash, scholarship, and science experience awards.

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